Nanoprobes

Nanoprobes was founded to develop the most sensitive reagents and technology for detecting biological molecules.

Our unique gold labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.

Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our probes a range and versatility which is not available with colloidal gold.

Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold labels; our unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy.

New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.

Our 1.4 nm Nanogold® probes have been cited in over 80 publications, and we are now developing larger cross-linkable labels in order to offer our customers larger covalently linkable probes with the same advantages.

Conjugates
with 1.4 nm Nanogold®
Antibody Conjugates
Fab' or IgG
FluoroNanogold™
Fluoroescent labeling
Lipid Conjugates
Also available in 0.8 nm
Streptavidin Conjugates
Enhancement / Developers
GoldEnhance™
Silver Enhancement
EnzMet™ ultra-sensitive
Enzymatic deposition of silver
for superfine detection

Gold Nanoparticles
3-5 nm, 2-4 nm, 1.4 nm, 0.8 nm
Positive, negative or uncharged
Various reactive groups
Hydrophobic or Hydrophilic
Histadine (His) Tag Labeling
Recombinant Protein Detection
GoldiBlot™ for Westerns
Ni-NTA-Nanogold®
Available in 5 nm & 1.8 nm
Magnetic nanoparticles
Superparamagnetic and biocompatible
Negative Stains
NanoVan® (vanadium)
Nano-W® (organotungsten)

Reagents with Nanogold®
Your choice of reactive groups
1.4 nm Nanogold®
0.8 nm Undecagold
Xray Contrast Agents
AuroVist™
5 nm & 1.8 nm
Unparalleled for microCT -
Try in vivo vascular casting!
EnzMet™ ultra-sensitive
Enzymatic deposition of silver
for superfine detection