CrownBio is a Cutting-Edge Translational Technology Company Making Precision Medicine a Reality

CrownBio brings clarity to drug discovery around the world by helping biopharmaceutical companies solve some of today's most pressing challenges in oncology and inflammation.

Our premier Translational Platforms for cancer and inflammation help our clients accelerate their new drug development programs. CrownBio develops world-leading preclinical efficacy models and provides both in vitro and in vivo testing services. We are a global company with facilities across the world, including in the United States, United Kingdom, Netherlands, China, and Taiwan.
We Help our Clients Accelerate Drug Discovery, Gain Insight and De-Risk Ushering Candidates into the Clinic

As a comprehensive solution provider, CrownBio helps reveal the best clinical possibilities with our proprietary HuPrime®, HuKemia®, HuBase™, HuMark™, HuTrial™, and HuSignature™ platforms enabling the rapid translation of a lead compound into a successful clinical candidate. CrownBio's cutting-edge, proprietary, Translational Technology Platforms provide robust and scientifically sound end-to-end solutions for preclinical drug development.
The Premier Translational Platforms for Advanced Drug Discovery

From large-scale in vitro and in vivo efficacy studies of drug candidates, to running surrogate trials in tandem with human clinical trials, CrownBio's well-characterized Translational Platforms deliver comprehensive and catered solutions for biopharmaceutical companies. By providing the data needed to inform and accelerate oncology and inflammation therapeutic development, CrownBio helps clients make smarter decisions about their drug candidates.

With more experience than anyone in the industry, CrownBio's global resources help customers answer the most challenging questions about human biology.

CrownBio's portfolio of cutting-edge technologies includes the world's largest commercial collection of validated patient-derived xenograft (PDX) models. At CrownBio we are seeking to recapitulate the diversity and complexity of human cancer biology in the laboratory.
Our Translational Technology Platforms are helping our clients make precision medicine a reality.

Models

Cell Line Derived Xenograft
HSC and PBMC Humanized
Human Target Knock-In ( HuGEMMTM )
Patient-Derived Xenograft ( HuPrimeTM )
Syngeneic
Tumor Homograft ( MuPrimeTM )

IMID

In Vivo Models

Inflammatory Bowel Disease (IBD)
MS-NASH (FATZO)
Rheumatoid Arthritis (RA)
Rodent Models of Diabetes

Biomarker Services

Flow Cytometry Platform
Histology and Digital Pathology Platform

Oncology

In Vivo Services

Breast Cancer Preclinical Models
Cell Line Derived Xenograft Models
Cell Line and Model Authentication
Custom Tumor Model Development
Immuno-Oncology Model
MuScreen
Orthotopic and Bioluminescent Models
Patient-Derived Xenograft Models (HuPrime/HuKemia)
Prostate Cancer Preclinical Model
Radiation Therapy
Syngeneic Tumor Models

In Vitro Services

Cell Based Screening
CrownSyn
Cell Line and Model Authentication
Cell Line Panels
Flow Cytometry Platform
Immuno-Oncology
OmniScreen Cell Based Screening Service
PDX-Derived Cell Lines

Organoids

Cell Line and Model Authentication
Organoid and Immune Cell Co-Culture

Ex Vivo Services

3D Assays
Tumor Microarrays

High Content Imaging

Immuno-Oncology

CAR-T Cell Therapy Models
Humanized Models
Hematopoietic Stem Cell (HSC)-PDX
MiXeno
Human Target Knock-In Models
HuGEMM
HuCELL
Murine Immunity Model and Services
Tumor Homograft
Syngeneic tumor
MuScreen
Mouse I/O RNA-Seq Panel

Oncology

Biomarker Discovery and CDx

Biomarkers of Response (HuMark)
Mouse Clinical Trials (HuTrial)
Signatures of Response (HuSignature)

Biomarker Assay Services

Clinical Chemistry and Biomarkers
Cytokine and Chemokine Profiling
Flow Cytometry
Genomics Services
Mouse I/O RNA-Seq Panel
Histology and Digital Pathology
Rare Cell Analysis

Bioinformatics

CrownSyn

Pharmacology and Bioanalytical Services

DMPK Services
Rodent Immuno-Safety Models
Rodent Safety Pharmacology
Structural Biology
Target Validation

Oncology Databases

HuBase
OrganoidBase
MuBase
OncoExpress
XenoBase