Sphere Bio, a Fluidic Sciences Ltd brand, is a company that specializes in single-cell analysis and isolation technology. The company's core business is centered around its picodroplet microfluidic technology, which enables the encapsulation of single cells in tiny droplets of aqueous fluid. This technology is used to develop high-throughput platforms, consumables, and reagents for single-cell isolation and analysis in various fields, including biologics discovery and development, cell engineering, synthetic biology, and cell therapy. The company's products, such as Cyto-Mine and Cyto-Mine Chroma, are designed to automate and streamline workflows, allowing researchers to screen millions of cells in a short amount of time, identify rare cells, and ensure monoclonality. Sphere Bio's technology aims to accelerate discoveries and breakthroughs in the life sciences industry by providing a robust, efficient, and reliable platform for single-cell analysis and isolation.

Sphere Fluidics’ platforms are built on over a decade of scientific and engineering research and development. Originally spun out from the University of Cambridge, we specialize in multiple technical areas to deliver miniaturization.

At the heart of our platforms are picodroplets. These are tiny droplets of aqueous fluid in an oil carrier fluid (a ‘single emulsion’) or an aqueous core surrounded by an oil shell in an aqueous carrier fluid (a ‘double emulsion’). Each picodroplet is used to encapsulate a cell. The chemistry of the emulsions is carefully designed to give long-term stable, biocompatible droplets with minimal leakage of molecules from the droplet, right down to small molecules such as metabolites. This provides an ultra-miniaturized test tube, containing media, reagents, and cells, that allows large-scale experiments at the single cell level.

Instruments
Cyto-Mine® Antibody Discovery and Cell Line Development workflows streamlined, like never before.
Pico-Mine® is our semi-automated platform designed to support earlier-stage research using picodroplet technology.
Spectra-Mine® The world's only platform that combines high-throughput picodroplet screening with real-time mass spectrometry measurement and selection of hits.

Consumables & Reagents
The consumables and reagents that underpin our picodroplet-based platforms are carefully crafted by our expert development and manufacturing teams. From best-in-class surfactants to sensitive and robust assay kits and microfluidic biochips, we take pride in knowing that you can rely on us.

Applications
Antibody Discovery
Cell Line Development
Cell Engineering
Cell Therapy
Synthetic Biology

2010